Iboga Doses.

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Iboga

Scientific Name(s): Tabernanthe iboga Baill.
Common Name(s): Bitter grass, Iboga, Ibogaine, Leaf of God, Thie-pelakano

Iboga

Scientific Name(s): Tabernanthe iboga Baill.
Common Name(s): Bitter grass, Iboga, Ibogaine, Leaf of God, Thie-pelakano

Clinical Overview

Use

Iboga has been used ritually as a hallucinogen. Studies suggest that ibogaine, one of the iboga alkaloids, has potential in the treatment of addiction to several substances. The US Drug Enforcement Agency (DEA) has placed ibogaine into Schedule I of the Controlled Substances Act (CSA).

Dosing

Strict medical supervision is necessary. Ibogaine has been used in single doses of 500 to 800 mg in a clinical study, and 17 mg/kg in a drug dependency treatment center.

Contraindications

Fatalities have been associated with the use of ibogaine; concomitant opioid use and comorbidities (eg, cardiovascular disease, depression, posttraumatic stress disorder, anxiety, stress, schizophrenia, epilepsy, or other imbalances in the autonomic nervous system) increase the risk of life-threatening complications including sudden cardiac death. Ibogaine should only be used under the supervision of an experienced health care provider.

Pregnancy/Lactation

Avoid use. Information regarding the safety and efficacy in pregnancy and lactation is lacking.

Interactions

None well documented.

Adverse Reactions

Mild acute effects occur frequently and include nausea, vomiting, ataxia, tremors, headaches, and mental confusion. Manic episodes lasting 1 to 2 weeks have also been reported and manifested as sleeplessness, irritability, impulsivity, emotional lability, grandiose delusions, rapid tangential speech, aggressive behavior, and suicidal ideation.

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BUY IBOGA ONLINEDosing

Strict medical supervision is necessary. Ibogaine has been used in single doses of 500 to 800 mg in a clinical study, and 17 mg/kg in a drug dependency treatment center.

Maximum blood levels and elimination half-life of ibogaine vary among individuals.Mash 2001 Due to documented toxicity, ibogaine should be used only under supervision of a health care provider experienced in its use.Vastag 2002

The authors of a review of clinical trial and toxicology data recommend a maximum oral dosage limit of less than 1 mg/kg as an initial dose in the treatment of drug dependence, which can then be increased incrementally, to avoid potentially life-threatening adverse effects.Vastag 2002

A single dose of ibogaine 500 to 800 mg has been used in clinical trials for the treatment of opioid addictionMash 2001; dividing the dose and administering smaller doses over several days or weeks has been suggested as a safer alternative.Glick 2001 An average single dose of 17 mg/kg has been used in a Brazilian clinic in combination with psychotherapy under close medical supervision with second, third, and fourth single-dose sessions provided at mean-time intervals of 245 days (±226 days), 303 days (±278 days), and 112 days (±100 days), respectively.Schenberg 2014

 

Other uses

The leishmanicidal activities of coronaridine and its synthetic analog 18-methoxycoronaridine have been studied in vitro.Delorenzi 2002 Both alkaloids demonstrated dose-dependent effects against the parasite but were nontoxic toward murine macrophages. Calculated 90% inhibitory concentrations were 22 and 16 mcg/mL for coronaridine and 18-methoxycoronaridine, respectively. Tabernanthine has cardiac conduction effects characteristic of a calcium channel antagonist; it also has other pharmacologic actions caused by the inhibition of cellular calcium metabolism and related to the turnover of intracellular calcium released by noradrenaline

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